The comedy will also star Debra Winger, Hank Azaria, Monica Potter and Rip Torn.
The black comedy follows three generations of a dysfunctional family that come together for the funeral of the family patriarch. A litany of family secrets and hidden relationships becomes evident during the gathering.
Michael Clancy wrote the script and will make his directing debut in the Artisan Pictures project. Filming begins Feb. 21.
Romano has been courted for several live-action projects, after doing voice work on the Fox animation hit 'Ice Age'. He is also circling the Rod Lurie-directed comedy 'Mooseport', but will do 'Eulogy' first.
Ryder, meanwhile, last starred opposite Adam Sandler in the Columbia hit 'Mr. Deeds'. But this will be her first job since the well-publicized trial that resulted in her conviction for grand theft and felony vandalism at Saks Fifth Avenue in Beverly Hills. Ryder was sentenced to three years probation and community service.
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